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KMID : 0380020060210060444
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Korean Journal of Biotechnology and Bioengineering
2006 Volume.21 No. 6 p.444 ~ p.450
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Skin Anti-aging Effect of Forsythia viridissima L. Extract
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Kim Mi-Jin
Kim Ja-Young
Jung Taek-Kyu
Choi Sang-Won
Yoon Kyung-Sup
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Abstract
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Skin anti-aging effect of Forsythia viridissima L. extract was evaluated by using antioxidant assay, expression of type I procollagen, and UVA-induced matrix metalloproteinase-1 in human dermal fibroblasts. Matairesinol-rich Forsythia viridissima L. extract was showed the scavenging activity of radicals and reactive oxygen species with the values of against 1,1-diphenyl-2-picrylhydrazly radical and against superoxide radicals in the xanthine/xanthine oxidase system, respectively. The type I procollagen was increased 33.76% by treatment with matairesinol-rich Forsythia viridissima L. extract, and UVA-induced MMP-1 was reduced 35.78% in a dose dependent manner. In the human skin irritation test, 2% matairesinol-rich Forsythia viridissima L. extract did not show any adverse effect. Also, the clinical study indicated that a cream group treated with 0.2% matairesinol-rich Forsythia viridissima L. extract significantly reduced skin wrinkles, as compared with a non-treated cream group (p < 0.05). These results suggest that Forsythia viridissima L. extract may be useful as a potential source of functional anti-aging cosmetics.
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KEYWORD
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Anti-aging, Forsythia viridissima L. extract, type I procollagen, matrix metalloproteinase-1, cosmetics
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